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lightsheet z.1 microscope  (Carl Zeiss)


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    Structured Review

    Carl Zeiss lightsheet z.1 microscope
    Lightsheet Z.1 Microscope, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/lightsheet+z%2E1+microscope/axio+microscope+observer+z1+%CE%B2/bio_rxiv__2025__06__18__660425-71-7-7
    Average 90 stars, based on 1 article reviews
    lightsheet z.1 microscope - by Bioz Stars, 2026-09
    90/100 stars

    Images

    Related Articles

    Imaging:

    Article Title: The people behind the papers - Yonit Maroudas-Sacks and Marko Popović.
    Article Snippet: The formation of a new head during Hydra regeneration involves the establishment of a head organizer that functions as a signaling center and contains an aster-shaped topological defect in the organization of the supracellular actomyosin fibers.. Here, we show that the future head region in regenerating tissue fragments undergoes multiple instances of extensive stretching and rupture events from the onset of regeneration.. These recurring localized tissue deformations arise due to transient contractions of the supracellular ectodermal actomyosin fibers that focus mechanical strain at defect sites.

    Article Title: Chemical-induced heart defects using a transgenic zebrafish model.
    Article Snippet: The capillary was immersed in a water chamber at 28.5 �C and connected with the Lightsheet Z.1 microscope (Zeiss) equipped with a 1.0 NA/20× W Plan water dipping objective and a CCD camera.

    Article Title: Three-Dimensional β-Amyloid Burden Correlation Between the Eye and Brain in Alzheimer's Disease Mice Using Light-Sheet Fluorescence Microscopy.
    Article Snippet: High-resolution LSFM imaging of ex vivo brain and eyeball samples was performed using a Zeiss Lightsheet Z.1 microscope (Carl Zeiss Meditec, Oberkochen, Germany) with a 5× illumination lens (0.1 NA) and a 5× objective lens (EC Plan-Neofluar, 0.16 NA; Carl Zeiss AG, Oberkochen, Germany) at a 0.71× zoom factor.

    Article Title: Timely neurogenesis drives the transition from nematic to crystalline nuclear packing during retinal morphogenesis
    Article Snippet: Imaging was performed on a Zeiss Lightsheet Z.1 microscope equipped with two PCO Edge 4.2 scientific complementary metal-oxide semiconductor cameras (max, 30 fps with 2048 × 2048 pixels) and with a 20×/1.2 Zeiss Plan-Apochromat water-immersion objective.

    Article Title: Genetic inactivation of the β1 adrenergic receptor prevents cerebral cavernous malformations in zebrafish
    Article Snippet: For imaging, the samples were placed in CUBICR2 as the imaging medium and imaged using a ZEISS Lightsheet Z.1 microscope.

    Article Title: Activated alpha 9 integrin expression enables sensory pathway reconstruction after spinal cord injury.
    Article Snippet: Confocal imaging was performed using a Zeiss LSM880 Airyscan microscope and lightsheet imaging was performed using Zeiss Lightsheet Z.1 microscope.

    Article Title: Multiscale Mechanics of Granular Biofilms
    Article Snippet: Light sheet imaging was performed using the Zeiss Lightsheet Z.1 microscope housed in the NRI-MCDB shared facility using the 20× CLARITY lens (refractive index = 1.46) combined with tile scanning.


    Microscopy:

    Article Title: The people behind the papers - Yonit Maroudas-Sacks and Marko Popović.
    Article Snippet: The formation of a new head during Hydra regeneration involves the establishment of a head organizer that functions as a signaling center and contains an aster-shaped topological defect in the organization of the supracellular actomyosin fibers.. Here, we show that the future head region in regenerating tissue fragments undergoes multiple instances of extensive stretching and rupture events from the onset of regeneration.. These recurring localized tissue deformations arise due to transient contractions of the supracellular ectodermal actomyosin fibers that focus mechanical strain at defect sites.

    Article Title: Chemical-induced heart defects using a transgenic zebrafish model.
    Article Snippet: The capillary was immersed in a water chamber at 28.5 �C and connected with the Lightsheet Z.1 microscope (Zeiss) equipped with a 1.0 NA/20× W Plan water dipping objective and a CCD camera.

    Article Title: Three-Dimensional β-Amyloid Burden Correlation Between the Eye and Brain in Alzheimer's Disease Mice Using Light-Sheet Fluorescence Microscopy.
    Article Snippet: High-resolution LSFM imaging of ex vivo brain and eyeball samples was performed using a Zeiss Lightsheet Z.1 microscope (Carl Zeiss Meditec, Oberkochen, Germany) with a 5× illumination lens (0.1 NA) and a 5× objective lens (EC Plan-Neofluar, 0.16 NA; Carl Zeiss AG, Oberkochen, Germany) at a 0.71× zoom factor.

    Article Title: Timely neurogenesis drives the transition from nematic to crystalline nuclear packing during retinal morphogenesis
    Article Snippet: Imaging was performed on a Zeiss Lightsheet Z.1 microscope equipped with two PCO Edge 4.2 scientific complementary metal-oxide semiconductor cameras (max, 30 fps with 2048 × 2048 pixels) and with a 20×/1.2 Zeiss Plan-Apochromat water-immersion objective.

    Article Title: Genetic inactivation of the β1 adrenergic receptor prevents cerebral cavernous malformations in zebrafish
    Article Snippet: For imaging, the samples were placed in CUBICR2 as the imaging medium and imaged using a ZEISS Lightsheet Z.1 microscope.

    Article Title: Activated alpha 9 integrin expression enables sensory pathway reconstruction after spinal cord injury.
    Article Snippet: Confocal imaging was performed using a Zeiss LSM880 Airyscan microscope and lightsheet imaging was performed using Zeiss Lightsheet Z.1 microscope.

    Article Title: Multiscale Mechanics of Granular Biofilms
    Article Snippet: Light sheet imaging was performed using the Zeiss Lightsheet Z.1 microscope housed in the NRI-MCDB shared facility using the 20× CLARITY lens (refractive index = 1.46) combined with tile scanning.


    Refractive Index:

    Article Title: The people behind the papers - Yonit Maroudas-Sacks and Marko Popović.
    Article Snippet: The formation of a new head during Hydra regeneration involves the establishment of a head organizer that functions as a signaling center and contains an aster-shaped topological defect in the organization of the supracellular actomyosin fibers.. Here, we show that the future head region in regenerating tissue fragments undergoes multiple instances of extensive stretching and rupture events from the onset of regeneration.. These recurring localized tissue deformations arise due to transient contractions of the supracellular ectodermal actomyosin fibers that focus mechanical strain at defect sites.

    Article Title: Chemical-induced heart defects using a transgenic zebrafish model.
    Article Snippet: The capillary was immersed in a water chamber at 28.5 �C and connected with the Lightsheet Z.1 microscope (Zeiss) equipped with a 1.0 NA/20× W Plan water dipping objective and a CCD camera.

    Article Title: Three-Dimensional β-Amyloid Burden Correlation Between the Eye and Brain in Alzheimer's Disease Mice Using Light-Sheet Fluorescence Microscopy.
    Article Snippet: High-resolution LSFM imaging of ex vivo brain and eyeball samples was performed using a Zeiss Lightsheet Z.1 microscope (Carl Zeiss Meditec, Oberkochen, Germany) with a 5× illumination lens (0.1 NA) and a 5× objective lens (EC Plan-Neofluar, 0.16 NA; Carl Zeiss AG, Oberkochen, Germany) at a 0.71× zoom factor.

    Article Title: Timely neurogenesis drives the transition from nematic to crystalline nuclear packing during retinal morphogenesis
    Article Snippet: Imaging was performed on a Zeiss Lightsheet Z.1 microscope equipped with two PCO Edge 4.2 scientific complementary metal-oxide semiconductor cameras (max, 30 fps with 2048 × 2048 pixels) and with a 20×/1.2 Zeiss Plan-Apochromat water-immersion objective.

    Article Title: Genetic inactivation of the β1 adrenergic receptor prevents cerebral cavernous malformations in zebrafish
    Article Snippet: For imaging, the samples were placed in CUBICR2 as the imaging medium and imaged using a ZEISS Lightsheet Z.1 microscope.

    Article Title: Activated alpha 9 integrin expression enables sensory pathway reconstruction after spinal cord injury.
    Article Snippet: Confocal imaging was performed using a Zeiss LSM880 Airyscan microscope and lightsheet imaging was performed using Zeiss Lightsheet Z.1 microscope.

    Article Title: Multiscale Mechanics of Granular Biofilms
    Article Snippet: Light sheet imaging was performed using the Zeiss Lightsheet Z.1 microscope housed in the NRI-MCDB shared facility using the 20× CLARITY lens (refractive index = 1.46) combined with tile scanning.


    Ex Vivo:

    Article Title: The people behind the papers - Yonit Maroudas-Sacks and Marko Popović.
    Article Snippet: The formation of a new head during Hydra regeneration involves the establishment of a head organizer that functions as a signaling center and contains an aster-shaped topological defect in the organization of the supracellular actomyosin fibers.. Here, we show that the future head region in regenerating tissue fragments undergoes multiple instances of extensive stretching and rupture events from the onset of regeneration.. These recurring localized tissue deformations arise due to transient contractions of the supracellular ectodermal actomyosin fibers that focus mechanical strain at defect sites.

    Article Title: Chemical-induced heart defects using a transgenic zebrafish model.
    Article Snippet: The capillary was immersed in a water chamber at 28.5 �C and connected with the Lightsheet Z.1 microscope (Zeiss) equipped with a 1.0 NA/20× W Plan water dipping objective and a CCD camera.

    Article Title: Three-Dimensional β-Amyloid Burden Correlation Between the Eye and Brain in Alzheimer's Disease Mice Using Light-Sheet Fluorescence Microscopy.
    Article Snippet: High-resolution LSFM imaging of ex vivo brain and eyeball samples was performed using a Zeiss Lightsheet Z.1 microscope (Carl Zeiss Meditec, Oberkochen, Germany) with a 5× illumination lens (0.1 NA) and a 5× objective lens (EC Plan-Neofluar, 0.16 NA; Carl Zeiss AG, Oberkochen, Germany) at a 0.71× zoom factor.

    Article Title: Timely neurogenesis drives the transition from nematic to crystalline nuclear packing during retinal morphogenesis
    Article Snippet: Imaging was performed on a Zeiss Lightsheet Z.1 microscope equipped with two PCO Edge 4.2 scientific complementary metal-oxide semiconductor cameras (max, 30 fps with 2048 × 2048 pixels) and with a 20×/1.2 Zeiss Plan-Apochromat water-immersion objective.

    Article Title: Genetic inactivation of the β1 adrenergic receptor prevents cerebral cavernous malformations in zebrafish
    Article Snippet: For imaging, the samples were placed in CUBICR2 as the imaging medium and imaged using a ZEISS Lightsheet Z.1 microscope.

    Article Title: Activated alpha 9 integrin expression enables sensory pathway reconstruction after spinal cord injury.
    Article Snippet: Confocal imaging was performed using a Zeiss LSM880 Airyscan microscope and lightsheet imaging was performed using Zeiss Lightsheet Z.1 microscope.

    Article Title: Multiscale Mechanics of Granular Biofilms
    Article Snippet: Light sheet imaging was performed using the Zeiss Lightsheet Z.1 microscope housed in the NRI-MCDB shared facility using the 20× CLARITY lens (refractive index = 1.46) combined with tile scanning.




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    Three-dimensional distribution of sympathetic nerve in the heart of Takotsubo syndrome (TTS) mice. ( A ) Bright field image of murine heart after CUBIC procedure. Scale bar, 2 mm. ( B ) Three-dimensional images of tyrosine hydroxylase (TH) (green)-stained and α-smooth muscle actin (α -SMA) (red)-stained heart samples observed using light sheet <t>microscope</t> (Lightsheet Z.1, Carl Zeiss). TH represents sympathetic nerves, and α -SMA is a marker of blood vessels. Scale bar, 2 mm. The right figures show higher magnified views of the boxed region in the left figure. Scale bar, 400 μm. ( C ) Three-dimensional images of the heart obtained from 4-week Sham and 4-week TTS mice. Heart samples were immunostained for TH (green). Sympathetic nerves in the inferior basal area and the inferior apical area were observed by confocal microscope (LSM700, Carl Zeiss). Scale bar, 200 μm. ( D ) Filament analysis of the sympathetic nerves (magenta) in 4-week Sham and 4-week TTS mice using the Imaris software. Scale bar, 200 μm. ( E ) Quantitative analysis of the sympathetic nerves. The ratio of the sympathetic nerve length in the inferior apical area to that in the inferior basal was statistically analyzed between 4-week Sham and 4-week TTS mice (n = 5 each). Statistical significance was determined using the Mann–Whitney U-test. *P < 0.05, vs. 4-week Sham mice. Error bars represent standard error of the mean.
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    Image Search Results


    Effect of MSCs on islet engraftment and revascularization. EZ Clear processed, wholemount lightsheet fluorescent microscopy imaged NICHE cell reservoir of islet‐loaded devices explanted at days A,B) 7 and C,D) 28; and islets + MSC‐loaded devices explanted at days E,F) 7 and G,H) 28. Islets are stained with insulin‐Alexa Flour 555 (green) and blood vessels are labeled with fluorescently conjugated Lycopersicon esculentum lectin (lectin‐DyLight 649). Scale bars; 1 mm (Top), 400 µm (bottom). I) Islet survival calculated as % of total islet volume loaded in NICHE. Blood vessel volume analysis of J) total cell reservoir and K) intra‐islet volume of no MSC ( n = 3/timepoint) and MSC co‐transplanted ( n = 3 /timepoint) devices. Mean ± SD, two‐way ANOVA with Bonferroni's multiple comparison (* p < 0.05).

    Journal: Advanced Science

    Article Title: Immune and Angiogenic Profiling of Mesenchymal Stem Cell Functions in a Subcutaneous Microenvironment for Allogeneic Islet Transplantation

    doi: 10.1002/advs.202411574

    Figure Lengend Snippet: Effect of MSCs on islet engraftment and revascularization. EZ Clear processed, wholemount lightsheet fluorescent microscopy imaged NICHE cell reservoir of islet‐loaded devices explanted at days A,B) 7 and C,D) 28; and islets + MSC‐loaded devices explanted at days E,F) 7 and G,H) 28. Islets are stained with insulin‐Alexa Flour 555 (green) and blood vessels are labeled with fluorescently conjugated Lycopersicon esculentum lectin (lectin‐DyLight 649). Scale bars; 1 mm (Top), 400 µm (bottom). I) Islet survival calculated as % of total islet volume loaded in NICHE. Blood vessel volume analysis of J) total cell reservoir and K) intra‐islet volume of no MSC ( n = 3/timepoint) and MSC co‐transplanted ( n = 3 /timepoint) devices. Mean ± SD, two‐way ANOVA with Bonferroni's multiple comparison (* p < 0.05).

    Article Snippet: [ ] They were imaged in EZ view solution using a Zeiss Lightsheet Z.1 microscope with a 5× lens at 0.5× zoom.

    Techniques: Microscopy, Staining, Labeling, Comparison

    Three-dimensional distribution of sympathetic nerve in the heart of Takotsubo syndrome (TTS) mice. ( A ) Bright field image of murine heart after CUBIC procedure. Scale bar, 2 mm. ( B ) Three-dimensional images of tyrosine hydroxylase (TH) (green)-stained and α-smooth muscle actin (α -SMA) (red)-stained heart samples observed using light sheet microscope (Lightsheet Z.1, Carl Zeiss). TH represents sympathetic nerves, and α -SMA is a marker of blood vessels. Scale bar, 2 mm. The right figures show higher magnified views of the boxed region in the left figure. Scale bar, 400 μm. ( C ) Three-dimensional images of the heart obtained from 4-week Sham and 4-week TTS mice. Heart samples were immunostained for TH (green). Sympathetic nerves in the inferior basal area and the inferior apical area were observed by confocal microscope (LSM700, Carl Zeiss). Scale bar, 200 μm. ( D ) Filament analysis of the sympathetic nerves (magenta) in 4-week Sham and 4-week TTS mice using the Imaris software. Scale bar, 200 μm. ( E ) Quantitative analysis of the sympathetic nerves. The ratio of the sympathetic nerve length in the inferior apical area to that in the inferior basal was statistically analyzed between 4-week Sham and 4-week TTS mice (n = 5 each). Statistical significance was determined using the Mann–Whitney U-test. *P < 0.05, vs. 4-week Sham mice. Error bars represent standard error of the mean.

    Journal: Scientific Reports

    Article Title: Phase dependent sympathetic dysinnervation in Takotsubo syndrome revealed with transparent heart

    doi: 10.1038/s41598-025-94349-8

    Figure Lengend Snippet: Three-dimensional distribution of sympathetic nerve in the heart of Takotsubo syndrome (TTS) mice. ( A ) Bright field image of murine heart after CUBIC procedure. Scale bar, 2 mm. ( B ) Three-dimensional images of tyrosine hydroxylase (TH) (green)-stained and α-smooth muscle actin (α -SMA) (red)-stained heart samples observed using light sheet microscope (Lightsheet Z.1, Carl Zeiss). TH represents sympathetic nerves, and α -SMA is a marker of blood vessels. Scale bar, 2 mm. The right figures show higher magnified views of the boxed region in the left figure. Scale bar, 400 μm. ( C ) Three-dimensional images of the heart obtained from 4-week Sham and 4-week TTS mice. Heart samples were immunostained for TH (green). Sympathetic nerves in the inferior basal area and the inferior apical area were observed by confocal microscope (LSM700, Carl Zeiss). Scale bar, 200 μm. ( D ) Filament analysis of the sympathetic nerves (magenta) in 4-week Sham and 4-week TTS mice using the Imaris software. Scale bar, 200 μm. ( E ) Quantitative analysis of the sympathetic nerves. The ratio of the sympathetic nerve length in the inferior apical area to that in the inferior basal was statistically analyzed between 4-week Sham and 4-week TTS mice (n = 5 each). Statistical significance was determined using the Mann–Whitney U-test. *P < 0.05, vs. 4-week Sham mice. Error bars represent standard error of the mean.

    Article Snippet: Scale bar, 2 mm. ( B ) Three-dimensional images of tyrosine hydroxylase (TH) (green)-stained and α-smooth muscle actin (α -SMA) (red)-stained heart samples observed using light sheet microscope (Lightsheet Z.1, Carl Zeiss).

    Techniques: Staining, Microscopy, Marker, Software, MANN-WHITNEY